Skip to main content
. 2022 May 6;23(9):5203. doi: 10.3390/ijms23095203

Figure 4.

Figure 4

Systemic and local tryptophan degradation rates. Apoe−/− or Apoe−/− Ido1−/− mice were fed a high-fat cholesterol diet (HFCD) for 7 weeks; pooled data from two independent experiments are shown. The L-kynrenine to Trp ratio (Kyn/Trp) in (A) plasma (n = 15–16), (B) artery homogenate (n = 14), and (C) liver homogenate (n = 15–16), was estimated using specific ELISA kits, as described in the methods. (D) shows the correlation between % lesion and Kyn/Trp ratio in the aorta. (E) shows the correlation between relative Cd68 mRNA and the Kyn/Trp ratio in the liver. *** p < 0.001; Differences were detected using the Mann–Whitney U test. Correlations were determined using simple linear regression.