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. 2022 Apr 28;23(9):4894. doi: 10.3390/ijms23094894

Figure 4.

Figure 4

Main acute-phase mediators associated with acute respiratory distress syndrome (ARDS) necessitating mechanical ventilation. (A) Receiver operator characteristic (ROC) curves of the six studied mediators with a statistically significant area under the ROC curve (AUC) for the detection of ARDS necessitating mechanical ventilation (MV). The AUCs, their 95% confidence intervals and significant p values are provided. The ROC curves of the other 14 mediators measured are not provided because they were not statistically significant. (B) Following Youden index analysis, the cut-offs of each of the six mediators shown in panel A were determined. These cut-offs were used in univariate and multivariate forward stepwise logistic regression analyses to select the mediators associated with ARDS necessitating MV. * variables excluded after three steps of forward analysis. Abbreviations: CI = confidence interval; OR = odds ratio.