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Correlations between global DNA methylation (5mC) and hydroxymethylation (5hmC) vs. mean sperm DNA fragmentation level in unfractionated sperm populations in the control C (a) and patient P (b) groups. Each point on the graph represents one case. For each male at least 1000 spermatozoa for TUNEL assay and 200 for IF epimark staining were examined. Statistical significance was considered at p < 0.05.
