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. 2022 Apr 28;11(9):1488. doi: 10.3390/cells11091488

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CDN1163 improves hepatosteatosis in db/db mice. (A) Hematoxylin and eosin staining of liver sections for control and db/db mice with either vehicle or CDM1163. Scale bars, 100 μm. (B) Percentage of lipid droplet area. The value was calculated as lipid droplet area divided by tissue area excluding luminal structures (n = 5 for each group). (C) Serum AST levels (n = 9 for each group). (D) Serum ALT levels (n = 9 for each group). (E) Serum fasted TG levels (Ctrl+veh, n = 4; Ctrl+CDN, n = 4; Db+veh, n = 5; Db+CDN, n = 4). (F) Serum TC levels (n = 9 for each group). Error bars represent SEM. * p < 0.05, ** p < 0.01, **** p < 0.0001 vs. Db+veh. AST, aspartate aminotransferase; ALT, alanine aminotransferase; Db, db/db mice; TG, triglyceride; TC, total cholesterol; NS, not significant.