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The intracellular cascade following ligand (calcium-) binding to the calcium-sensing receptor. Abbreviations: Ca2+, calcium; CaSR, calcium sensing receptor; AP2S1, adaptor-related protein complex 2 subunit 2; Gi, inhibitory G-protein; cAMP, cyclic adenosine monophosphate; PLC, phospholipase C; PIP3, phosphatidylinositol-3,4,5-triphosphate; DAG, diacylglycerol; PKC, protein kinase C.
