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Giant cell tumor of bone: the characteristic mixture of osteoclast-like giant cells (A, black arrow, HE, 200×; B, black arrow, HE, 400×), and mononuclear neoplastic cells (A, white arrow, HE, 200×; C, white arrow, HE, 400×); some of the giant-cells have >50 nuclei per cell (D, HE, 600×); hemorrhages (E, HE, 200×), and field of foamy macrophages (E, arteriks, HE, 200×; F, arteriks, HE, 400×) are present in majority of cases.
