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Giant cell tumor of bone: predominant mononuclear cells (A, HE, 100×; B) with strong nuclear expression of H3.3 p.Gly34Trp (G34W) (B, G34W, 100×); the giant cells (C, HE, 100×; D, G34W, 100×) are negative for H3.3 p.Gly34Trp (G34W) but positive reaction in mononuclear cells are described in over 90% of cases (D, G34W, 100×).
