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Significant calcification of the locally advanced GCTB of proximal tibia after 8 doses of denosumab (X-rays). Prolonged denosumab treatment can aid resection of the initially inoperable cases. (A): Lesion before denosumab therapy, (B): after 8 doses of denosumab, (C): after the surgery with radical resection and implantation of oncological prosthesis.
