Table 2.
Mouse uterine pathology.
| Pathology Results, n (%) | ||||||
|---|---|---|---|---|---|---|
| Genotype | Diet | Mice (n) | Normal | Hyperplasia | Atypical Hyperplasia |
Cancer |
| Lkb1+ /+ | Chow | 4 | 1 (25%) | 2 (50%) | 1 (25%) | |
| Lkb1+ /+ | Western | 4 | 1 (25%) | 3 (75%) | ||
| Sprr2f-Cre; Lkb1L /+ | Chow | 24 | 3 (12.5%) | 6 (25%) | 14 (58.3%) | 1 (4.2%) |
| Sprr2f-Cre; Lkb1L /+ | Western | 29 | 8 (27.6%) | 7 (24.1%) | 13 (44.8%) | 1 (3.5%) |
Statistical analyses display that for all genotypes combined, there is no significant difference in Chow vs. Western/Normal vs. Disease contingency (p = 0.52 Fisher’s Exact) or Chow vs. Western/Normal vs. Hyperplasia vs. Atypical Hyperplasia (no cancer) Chi-square = 0.95, p = 0.62. Lkb1 (liver kinase B1), Cre (cre recombinase), Sprr2f (small proline-rich protein 2F), Lkb1+/+ (mice are wild-type for LKB1 in the endometrium), Sprr2f-Cre; Lkb1L/+ (mice are heterozygous for LKB1 in the endometrium).