2D-DIGE	two-dimensional differential gel electrophoresis
2-DE	two-dimensional gel electrophoresis
A1AG	α-1-acid-glycoprotein
A1BG	α-1-B-glycoprotein
ACE	angiotensin-converting enzyme
ADEM	acute disseminated encephalomyelitis
ALS	amyotrophic lateral sclerosis
ANO2	anoctamine-2
BBB	blood–brain barrier
BDNF	brain-derived neurotrophic factor
CCL11	Eotaxin-1
CCL20	chemokine ligand 20
CCN5	connective tissue growth factor/cysteine-rich protein/nephroblastoma overexpressed-5
CDMS	clinically definitive multiple sclerosis
CHI3L1	Chitinase-3-like protein 1
CHI3L2	Chitinase-3-like protein 2
CIDP	chronic inflammatory demyelinating polyneuropathy
CIS	clinically isolated syndrome
CNS	central nervous system
COX5b	cytochrome C oxidase subunit 5b
CSF	cerebrospinal fluid
DIS	dissemination in space
DIT	dissemination in time
DMF	dimethyl-fumarate
DMT	disease modifying therapy
EAE	experimental autoimmune encephalomyelitis
EAN	European Academy of Neurology
EBV	Epstein–Barr virus
ECTRIMS	European Committee for Treatment and Research in Multiple Sclerosis
EDSS	expanded disability status scale
ELISA	enzyme-linked immunosorbent assay
FNG	fingolimod
GA	glatiramer-acetate
Gd+	gadolinium
GFAP	glial fibrillary acidic protein
GPI	glucose-6-phosphate isomerase
ICAT	Isotope-coded affinity tag labeling
IEC	ion exchange chromatography
IFN-β	interferon-β
IGF2	insulin-like growth factor 2
IGFBP7	insulin-like growth factor-binding protein 7
iTRAQ	isobaric tag for relative and absolute quantitation
LC-TMS	liquid chromatography–tandem mass spectrometry
LHON	Leber’s Hereditary Optic Neuropathy
MAPK	mitogen-activated protein kinase
MBP	myelin basic protein
MDR	multidrug response
MOG	myelin oligodendrocyte glycoprotein
MRI	magnetic resonance imaging
MS	multiple sclerosis
MSSS	multiple sclerosis severity score
NAT	natalizumab
NEDA	no evidence of disease activity
nFL	neurofilament light chain
NMOSD	neuromyelitis optica spectrum disorder
NMR spectroscopy	nuclear magnetic resonance spectroscopy
OGP	oligoclonal gammopathy
PEPB1	phosphatidylethanolamine-binding protein 1
PKCθ	protein kinase C θ
PKN	prior knowledge signaling network
PLP-1	proteolipid protein
PPMS	primary progressive multiple sclerosis
PRDX6	peroxiredoxin 6
Prx1	peroxiredoxin-1
QoL	quality of life
RAAS	renin–angiotensin–aldosterone system
ROS	reactive oxygen species
RRMS	relapsing-remitting multiple sclerosis
RTN3	reticulon 3
SAP	serum amyloid P component
Scg1	secretogranin-1
SDS-PAGE	sodium dodecyl sulfate-polyacrylamide gel electrophoresis
SEC	size exclusion chromatography
SERPINA3	α-1-antichymotrypsin
SILAC	stable isotope labeling with amino acids in cell culture
SIRTs	silent information regulator proteins
SLE	systemic lupus erythematosus
SPMS	secondary progressive multiple sclerosis
SST	somatostatin
STAT	signal transducer and activator of transcription
TAK1	TGF-β-activated kinase 1
TER	teriflunomide
TGF-β	transforming growth factor beta
TNF	tumor necrosis factor
VILIP-1	visinin-like protein
vWF	von Willebrand factor