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. 2022 May 5;14(9):2299. doi: 10.3390/cancers14092299

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Thymic small cell carcinoma. (A) This tumor grows in nests and small sheets of tumor cells. (B) The tumor cells are medium-sized, have a high nuclear-to-cytoplasmic ratio and dark, finely dispersed nuclear chromatin. (C) The tumor cells are negative for GLUT1 (note staining in erythrocytes). (D) The tumor cells are also negative for CD5 (note clusters of CD5-positive T lymphocytes/thymocytes). (E) TdT highlights clusters of thymocytes in between nests of tumor cells. (F) CD117 is expressed in 100% of tumor cells. Magnification, H&E ×40 (A), ×200 (B), GLUT1 ×200 (C), CD5 ×200 (D), TdT ×200 (E), CD117 ×200 (F).