Table 2.

Echocardiographic parameters at baseline and follow-up during chemotherapy.

				Unmatching			Matching *
	Dox-ICI Cohort (n = 22)			Dox Cohort (n = 73)			Dox Cohort (n = 22)
	Baseline	6-Month	p Value	Baseline	6-Month	p Value	Baseline	6-Month	p Value
LVEF, %	65 ± 5	56 ± 8	0.003	66 ± 6	59 ± 6	<0.001	66 ± 6	60 ± 9	<0.001
Change in LVEF, %	−9.3 ± 2.1			−7.0 ± 1.3		0.376	−6.9 ± 1.9		0.188 †
(Absolute change)
LVEDD, mm	47 ± 3	45 ± 2	0.291	48 ± 3	48 ± 2	0.674	48 ± 3	48 ± 2	0.624
LVESD, mm	30 ± 2	31 ± 1	0.952	31 ± 3	32 ± 3	0.856	31 ± 3	33 ± 3	0.122
LAVI, mL/m2	27.6 ± 1.3	27.5 ± 2.1	0.965	27.8 ± 11.0	28.4 ± 12.0	0.776	27.8 ± 11.0	28.8 ± 7.2	0.650
E velocity, cm/s	0.68 ± 0.16	0.58 ± 0.28	0.127	0.69 ± 0.16	0.65 ± 0.20	0.196	0.69 ± 0.16	0.64 ± 0.18	0.095
A velocity, cm/s	0.63 ± 0.24	0.51 ± 0.29	0.051	0.64 ± 0.16	0.67 ± 0.17	0.332	0.64 ± 0.16	0.67 ± 0.17	0.148
S’, cm/s	8.42 ± 2.06	6.15 ± 3.19	<0.001	8.1 ± 1.5	7.2 ± 2.2	0.698	8.1 ± 1.5	7.2 ± 2.2	0.375
e’, cm/s	8.12 ± 2.39	6.07 ± 3.27	0.007	8.1 ± 2.7	7.0 ± 2.6	0.449	8.1 ± 2.7	7.1 ± 2.3	0.225
a’, cm/s	9.21 ± 3.30	6.89 ± 4.28	0.01	8.7 ± 1.8	8.1 ± 2.3	0.101	8.7 ± 1.8	8.1 ± 2.3	0.419
E/e’ ratio	8.76 ± 2.27	9.60 ± 2.27	0.602	9.1 ± 2.7	9.8 ± 4.1	0.209	9.1 ± 2.7	9.6 ± 2.9	0.589
PASP, mmHg	22 ± 9	27 ± 9	0.504	26 ± 7	28 ± 9	0.353	26 ± 7	28 ± 8	0.267
LVGLS, %	−18.6 ± 1.9	−15.3 ± 3.6	0.015	−17.3 ± 2.3	−15.4 ± 3.6	<0.001	−17.3 ± 2.3	−15.6 ± 2.8	<0.001
Change in LVGLS, %	−12.4 ± −2.4			−10.1 ± −1.9		0.392	−10.0 ± −1.8		0.296 †
(Relative change)

* Matching for age, sex and adriamycin cumulative dose. † p for Dox-ICI group and matching Dox group.