Figure 1.

Physiological regulators of aldosterone secretion. Several stimuli can induce the release of aldosterone by the adrenal cortex via the renin-angiotensin system. These include a reduction in renal perfusion pressure, sensed by juxtaglomerular cells, a decrease in NaCl delivery to the macula densa and an increase in sympathetic activity. Moreover, hyperkalemia can directly stimulate aldosterone secretion from adrenal cortex. Finally, the adrenocorticotropic hormone (ACTH) can act as an aldosterone secretagogue, although it plays a minor role in its regulation.