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Biosynthesis and structure of O-linked chains. The sugar O-glycosidically linked to Ser/Thr can be GalNAc (A), as in Mucin-type O-glycosylation; GlcNAc (B), as in many cytosolic and nuclear proteins; fucose (C), as in NOTCH receptors; or mannose (D), as in dystroglycan. Enzymes catalyzing core glycosylation are boxed in black, those catalyzing chain extensions are boxed in green, while those catalyzing chain cappings are boxed in violet.
