Table 2.

Glycosyltransferases show an association with prognosis in a large number of cohorts.

Pathway	Enzyme	Activity	Product	Score
Core N-glycosylation	ALG3	α1,3-mannosyltransferase	Mannosylated precursor	9
	ALG8	α1,3-glucosyltransferase	Glucosylated precursor	7
	MGAT4B	β1,4 GlcNAc transferase B	β1,4-branched N-glycans	6
Core O-glycosylation (mucin type)	GALNT2	Protein:O-GalNAC transferase 2	Tn-antigen	8
	GALNT10	Protein:O-GalNAC transferase 10	Tn-antigen	5
	GALNT16	Protein:O-GalNAC transferase 16	Tn-antigen	−6
O-fucosylation	POFUT1	Protein O-fucosyltransferase 1	O-fucosylated NOTCH	7
Core of Glycolipids	B4GALT5	β1,4-Galactosyltransferase 5	Lactosylceramide	8
	B4GALNT1	β1,4-GalNAc transferase 1	Ganglioside GM2, asialo GM2	8
Chain extension	B3GNT4	β1,3-GlcNAc transferase 4	Type 2 polylactosaminic chains	5
	B3GNT5	β1,3-GlcNAc transferase 5	Lactotriaosylceramide	7
	B3GNT7	β1,3-GlcNAc transferase 7	Type 2 polylactosaminic chains	6
	B3GNT9	β1,3-GlcNAc transferase 9	Polylactosamines O-linked	5
	B4GALT3	β1,4-Galactosyltransferase 3	Type 2 lactosaminic chains	7
	B3GALT4	β1,3-Galactosyltransferase 4	Type 1 lactosaminic chains	−5
O-mannosylation	LARGE	Xylosyltransferase and β1,3-glucuronyltransferase	Elongated O-mannosyl glycans	−6
Capping	ST3GAL2	α2,3 to Gal sialyltransferase 2	Sialyl-T; Gangliosides GD1a, GM1b, GT1b	6
	ST3GAL4	α2,3 to Gal sialyltransferase 4	Sialyl-T; N-glycans; Gangliosides GD1a, GM1b	6
	ST6GALNAC3	α2,6 to GalNAc sialyltransferase 3	Di-sialyl T; Gangliosides GD1α, GM1b	6
	ST6GALNAC4	α2,6 to GalNAc sialyltransferase 4	Di-sialyl T; Ganglioside GD1α	5
	FUT7	α1,3/6 fucosyltransferase 7	Sialyl Lewis X	−6

BPA and GPA have positive or negative score values, respectively. Scores marked in bold refer to those enzymes that were associated with bad or good prognosis in all the cohorts with predictive value.