Table 4.

Binding free energies calculated by molecular docking.

Substrate	ΔG Binding CTX-M-15 (kcal mol−1)	ΔG Binding CTX-M-15 S70A (kcal mol−1)
Clavulanic acid	−6.2	−6.0
Nitrocefin	−6.7	−7.4
Ceftiofur	−6.8	−7.6
Ampicillin	−6.9	−7.4
DFC	−7.5	−8.6