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. 2022 Apr 25;11(9):2400. doi: 10.3390/jcm11092400

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Kaplan–Meier survival analyses on DFS curves to differentiate recurrence in patients with stage I to III CRC by individual and combined biomarkers. (A–D) DFS curve to differentiate recurrence in patients with stage I to III CRC stratified by numbers of CTC (A), serum CEA level (B), CA19-9 (C) and presence of CTM (D), individually. (E) DFS curve to differentiate recurrence in patients with stage I to III CRC stratified by considering the combination of plasma miR-21 and CTM. (F) DFS curve to differentiate recurrence in patients with stage I to III CRC stratified by considering the combination of plasma and exosomal miR-21.