Table 1.

Preoperative demographics, classifications, and pathological parameters of 113 CRC patients (* p < 0.05; ** p < 0.01; *** p < 0.001).

		Exosome miR21 in PB			Plasma miR21 in PB			CTCs in PB			CTM in PB
	Total	High	Low	p	High	Low	p	High	Low	p	High	Low	p
	N = 113	N = 37	N = 76		N =20	N = 93		N = 11	N = 102		N = 9	N = 104
Age	65.19	67.08	64.28		66.5	64.91		65.19	69.45			61.22	65.54
	(39–93)	(42–93)	(39–90)		(42–93)	(39–92)		(49–85)	(39–92)			(40–83)	(39–93)
Gender
Male	77 (68%)	26	51	0.8311	13	64	0.7936	6	71	0.3231	6	71	>0.9999
Female	36 (32%)	11	25		7	29		5	31		3	33
TNM Stage
I	36 (32%)	10	26	0.7189	3	33	0.0003 ***	3	33		3	33	0.0788
II	31 (27%)	11	20		6	25		2	29	0.6896	1	30
III	35 (31%)	11	24		4	31		4	31		2	33
IV	11 (10%)	5	6		7	4		2	9		3	8
T stage
T1–T2	39 (35%)	10	29	0.2947	3	36	0.0674	3	36	0.7454	3	36	>0.9999
T3–T4	74 (65%)	27	47		17	57		8	66		6	68
N stage
N0	70 (62%)	23	47	0.4572	11	59	0.0133 *	6	64	0.2162	6	64	0.9487
N1	30 (27%)	8	22		3	27		2	28		2	28
N2	13 (12%)	6	7		6	7		3	10		1	12
M stage
M0	102 (90%)	32	70	0.4996	13	89	0.0004 ***	9	93	0.2905	6	96	0.0422 *
M1	11 (10%)	5	6		7	4		2	9		3	8
Tumor size (cm2)
≥5	24 (21%)	12	12	0.0521	7	17	0.1302	5	19	0.0537	2	22	>0.9999
<5	89 (79%)	25	64		13	76		6	83		7	82
Differentiation
Poor	5 (4%)	1	4	0.8246	1	4	0.7619	1	4	0.2641	1	4	0.1449
Moderate	105 (93%)	35	70		18	87		9	96		7	98
Well	3 (3%)	1	2		1	2		1	2		1	2
Location
Right colon	26 (23%)	10	16	0.7366	4	22	0.3203	4	22	0.0781	2	24	0.8861
Left colon	57 (50%)	17	40		8	49		2	55		4	53
Rectal	30 (27%)	10	20		8	22		5	25		3	27
CEA (5 ng/mL)
>5	38 (34%)	15	23	0.2958	9	29	0.2977	5	33	0.5032	8	30	0.0006 ***
≤5	75 (66%)	22	53		11	64		6	69		1	74
CA19-9 (U/mL)
>37	15 (13%)	10	5	0.0058 **	6	9	0.0257 *	3	11	0.1371	1	13	>0.9999
≤37	98 (87%)	27	71		14	84		8	91		8	91
Treatments
pre-operation	18 (16%)	6	12	>0.9999	5	13	0.3086	2	16	0.6871	2	16	0.6335
non-pre operation	95 (84%)	31	64		15	80		9	86		7	88