Table 2.
Recurrence rate and odds ratios (ORs) of several biomarkers individually and combined to predict CRC recurrence in 113 patients in all stages (* p < 0.05; ** p < 0.01; **** p < 0.0001).
| All Stages | Number of Cases | Recurrence Rate (%) | Odds Ratio | |
|---|---|---|---|---|
| 113 Cases | Recurrence (+) | Recurrence (−) | ||
| High Exosome miR-21 | 7 | 30 | 18.9 | 17.5 |
| Low Exosome miR-21 | 1 | 75 | 1.3 | p value = 0.0016 ** |
| High Plasma miR-21 | 7 | 12 | 37 | 54.3 |
| Low Plasma miR-21 | 1 | 93 | 1.1 | p value < 0.0001 **** |
| High CTC | 3 | 8 | 27.3 | 7.3 |
| Low CTC | 5 | 97 | 4.9 | p value = 0.0298 * |
| Presence of CTM | 2 | 7 | 22.2 | 4.7 |
| Absence of CTM | 6 | 98 | 5.8 | p value = 0.123 |
| CEA > 5 ng/mL | 4 | 34 | 10.5 | 2.1 |
| CEA ≤ 5 ng/mL | 4 | 71 | 5.3 | p value = 0.4388 |
| CA19-9 > 37 U/mL | 3 | 12 | 20 | 4.7 |
| CA19-9 ≤ 37 U/mL | 5 | 93 | 5.1 | p value = 0.071 |
| High Exosome miR-21 | 6 | 8 | 42.9 | 36.4 p value < 0.0001 **** |
| High Plasma miR-21 | ||||
| Others | 2 | 97 | 2 | |
| High Exosome miR-21 | 3 | 3 | 50 | 20.4 p value = 0.0043 ** |
| High Plasma miR-21 | ||||
| High CTC | ||||
| Others | 5 | 102 | 4.7 | |
| High Exosome miR-21 | 1 | 1 | 50 | 14.9 p value = 0.1372 |
| High Plasma miR-21 | ||||
| With CTM | ||||
| Others | 7 | 104 | 6.3 | |
| High Exosome miR-21 | 4 | 5 | 44.4 | 20 p value = 0.0012 ** |
| High Plasma miR-21 | ||||
| CEA > 5 ng/mL | ||||
| Others | 4 | 100 | 3.8 | |
| High Exosome miR-21 | 3 | 3 | 50 | 20.4 p value = 0.0043 ** |
| High Plasma miR-21 | ||||
| CA19-9 > 37 U/mL | ||||
| Others | 5 | 102 | 4.7 | |