Table 1.
Polymyxin B, colistin, and the novel polymyxin based analogs with improved efficacy in animal infection models [51] a,b.
| Compound | FA | Sequence |
|---|---|---|
| Polymyxin B (PMB) | Methyloctanoyl/methylheptanoyl | Dab1-Thr2-Dab3-cy[Dab4-Dab5-DPhe6-Leu7-Dab8-Dab8-Thr10] |
| Polymyxin E (PME, Colistin) | Methyloctanoyl/methylheptanoyl | Dab1-Thr2-Dab3-cy[Dab4-Dab5-DLeu6-Leu7-Dab8-Dab8-Thr10] |
| FADD002 | Octanoyl | Dab1-Thr2-Dab3-cy[Dab4-Dab5-DAda6-Leu7-Dab8-Dab8-Thr10] |
| FADD287 | Octanoyl | Dab1-Thr2-Dap3-cy[Dab4-Dab5-DLeu6-Abu7-Dab8-Dab8-Thr10] |
| CA284 | (S)-1-(2-methylpropyl)-piperazine-2-carbonyl+ | Thr1-Dab2-cy[Dab3-Dab4-DPhe-Leu6-Dab7-Dab8-Thr9] |
| SPR206 | (3S)-4-amino-3-(3-chlorophenyl)butanoyl | Thr1-Dab2-cy[Dab3-Dab4-DPhe-Leu6-Dab7-Dab8-Thr9] |
| MicuRx-12 | 3-(2,2-dimethyl-butanoyloxy)-propanoyl (ester bond) | Dab1-Thr2-Dab3-cy[Dab4-Dab5-DPhe6-Leu7-Dab8-Dab8-Thr10] |
| NAB379 | Octanoyl | Thr1-DSer2-cy[Dab3-Dab4-DPhe5-Leu6-Dab7-Dab8-Thr9] |
| NAB815 | Octanoyl | Dab1-Thr2-DThr3-cy[Dab4-Dab5-DPhe6-Leu7-Abu8-Dab8-Thr10] |
a Amino acyl residues that differ from those in polymyxin B are marked in Red, b Abu, aminobutyryl; Ada, aminodecanoyl; Dap, diaminopropionyl; cy, cyclic region indicated with brackets; Dab, diaminobutyryl; FA, fatty acyl.