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Membrane PS-dependent signaling mechanisms modulated by DHA that mediate neuronal survival under adverse conditions. By increasing PS in the neuronal membrane, DHA facilitates the translocation and activation of PKC, Raf-1, and Akt, positively influencing neuronal survival. PKC, protein kinase C; ERK, mitogen-activated kinase (MAPK); MEK, MAPK kinase. PC, phosphatidylcholine; PE, phosphatidylethanolamine; PS, phsphatidylserine. Adapted from reference [12].
