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. 2022 Apr 22;23(9):4635. doi: 10.3390/ijms23094635

Figure 5.

Figure 5

Synaptamide-activated GPR110 signaling. By binding to GPR110, synaptamide activates Gαs protein; increases cAMP; promotes neurogenesis, neurite growth, and synaptogenesis; and inhibits neuroinflammation. DHA, docosahexaenoic acid; FAAH, fatty acid amide hydrolase; GAIN, GPCR autoproteolysis domain; GTP, guanosine-5′-triphosphate; GDP, guanosine-5′-diphosphate; ATP, adenosine-5′-triphosphate; AC, adenylyl cyclase; CREB, cAMP response element-binding protein. Adapted from references [15,49].