Figure 6.

Activation of GPR110 and downstream signaling through synaptamide binding to the GAIN domain. Synaptamide is shown with a space-filling or stick-and-ball representation. Synaptamide binds to the interface between two subdomains, causing conformational changes in the GAIN and intracellular domains of GPR110 (depicted by red arrows) that trigger downstream signaling events. Adapted from reference [56]. GAIN, GPCR autoproteolysis domain; GTP, guanosine-5′-triphosphate; GDP, guanosine-5′-diphosphate.