Table 2.
Summary of the in vitro interactions of isavuconazole with colistin against common Candida species evaluated by EUCAST broth microdilution checkerboard methodology and interpretation by fractional inhibitory concentration index and response surface analysis.
| Species (strains), interpretation model | % of strains with the following interaction | ||
|---|---|---|---|
| Synergy | Indifference | Antagonism | |
| Candida albicans (10), FICI | 0 | 100 | 0 |
| C. albicans (10), RSA | 0 | 100 | 0 |
| Candida glabrata (10), FICI | 90 | 10 | 0 |
| C. glabrata (10), RSA | 10 | 90 | 0 |
| Candida krusei (10) FICI | 80 | 20 | 0 |
| C. krusei (10), RSA | 50 | 50 | 0 |
| Candida parapsilosis (9), FICI | 33 | 67 | 0 |
| C. parapsilosis (9), RSA | 0 | 100 | 0 |
| Candida tropicalis (10), FICI | 90 | 10 | 0 |
| C. tropicalis (10), RSA | 50 | 50 | 0 |
| Candida kefyr (8), FICI | 50 | 50 | 0 |
| C. kefyr (8), RSA | 63 | 37 | 0 |
FICI, fractional inhibitory concentration index; RSA, response surface analysis; EUCAST, European Committee on Antimicrobial Susceptibility Testing.