Table 3.
Complement levels on admission in patients with COVID-19 in combined cohort, and in US and Hungary separately, stratified by need for renal replacement therapy (RRT).
| Variable | Combined Cohort | US Cohort | Hungarian Cohort | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Total (n = 131) |
No need for RRT (n = 119) |
Need for RRT (n = 12) |
p | Total (n = 33) |
No need for RRT (n = 25) |
Need for RRT (n = 8) | p |
Total (n = 98) |
No need for RRT (n = 94) |
Need for RRT (n = 4) |
p | ||
| C3 | Below | 16 | 15 (12.6%) | 1 (8.3%) | 0.87 | 2 | 1 (4%) | 1 (12.5%) | 0.43 | 14 | 14 (14.9%) | 0 (0,0%) | 0.9 |
| Normal | 99 | 90 (75.6%) | 9 (75%) | 19 | 14 (56%) | 5 (62.5%) | 80 | 76 (80.9%) | 4 (100%) | ||||
| Above | 16 | 14 (11.8%) | 2 (16.7%) | 12 | 10 (40%) | 2 (25%) | 4 | 4 (4.2%) | 0 (0,0%) | ||||
| C3a | Below | – | 0.001 | 0.9 | 0.04 | ||||||||
| Normal | 54 | 54 (46.2%) | 0 (0%) | 1 | 1 (4%) | 0 (0%) | 53 | 53 (57.6%) | 0 (0,0%) | ||||
| Above | 75 | 63 (53.8%) | 12 (100%) | 32 | 24 (96%) | 8 (100%) | 43 | 39 (42.4%) | 4 (100%) | ||||
| C3a/C3 | 1.86 (1.27–3.02) | 1.79 (1.24–2.81) | 3.42 (3.15–3.63) | <0.001 | 2.18 (1.48–3.01) | 1.65 (1.28–2.49) | 3.24 (2.86–3.38) | 0.002 | 1.84 (1.25–3.03) | 1.79 (1.23–2.97) | 3.7 (3.54–4.84) | 0.01 | |
All continuous data presented as median (IQR), with P-values calculated using Mann-Whitney's U test. All categorical data presented as frequency (%), with P-values calculated using Fisher's exact test. RRT, renal replacement therapy. Statistical significance denoted with bold text.