Table 5.
Spearman's Correlation coefficients between complement parameters and other circulating biomarkers measured on admission.
| Hungarian cohort | US cohort | ||||||
|---|---|---|---|---|---|---|---|
| Alternative Pathway | Classical pathway | C3a | C4 | C3a/C3 | Factor I | C3a/C3 | |
| ED Creatinine | −0.079 (p = 0.44) | −0.179 (p = 0.08) | 0.144 (p = 0.16) | −0.066 (p = 0.52) | 0.276 (p = 0.006) | −0.499 (p = 0.003) | 0.696 (p = 0.001) |
| ADAMTS13 | 0.491 (p = 0.001) | 0.269 (p = 0.007) | −0.183 (p = 0.07) | 0.310 (p = 0.002) | −0.318 (p = 0.001) | 0.389 (p = 0.03) | −0.398 (p = 0.02) |
| vWF | −0.164 (p = 0.12) | −0.152 (p = 0.15) | 0.387 (p < 0.001) | −0.077 (p = 0.47) | 0.370 (p < 0.001) | 0.182 (p = 0.31) | 0.133 (p = 0.46) |
| ADAMTS13/vWF:Ag | 0.395 (p < 0.001) | 0.245 (p = 0.02) | −0.353 (p < 0.001) | 0.259 (p = 0.01) | −0.441 (p < 0.001) | 0.131 (p = 0.47) | −0.407 (p = 0.02) |
| CRP | 0.034 (p = 0.74) | 0.128 (p = 0.21) | 0.618 (p < 0.001) | 0.160 (p = 0.12) | 0.475 (p < 0.001) | 0.149 (p = 0.41) | 0.284 (p = 0.11) |
| Ferritin | −0.037 (p = 0.73) | 0.016 (p = 0.88) | 0.392 (p < 0.001) | 0.032 (p = 0.76) | 0.305 (p = 0.003) | −0.188 (p = 0.30) | 0.365 (p = 0.04) |
| IL-6 | −0.130 (p = 0.21) | −0.028 (p = 0.79) | 0.340 (p < 0.001) | 0.067 (p = 0.51) | 0.298 (p = 0.003) | −0.139 (p = 0.45) | 0.419 (p = 0.02) |
| Fibrinogen | 0.305 (p = 0.01) | 0.371 (p = 0.002) | 0.141 (p = 0.25) | 0.260 (p = 0.03) | −0.026 (p = 0.83) | 0.537 (p = 0.006) | 0.021 (p = 0.92) |
| LDH | −0.119 (p = 0.26) | −0.161 (p = 0.13) | 0.289 (p = 0.006) | −0.194 (p = 0.07) | 0.320 (p = 0.002) | −0.150 (p = 0.41) | 0.220 (p = 0.22) |
| Lymphocytes | 0.230 (p = 0.02) | −0.031 (p = 0.76) | −0.296 (p = 0.004) | −0.144 (p = 0.16) | −0.279 (p = 0.006) | 0.067 (p = 0.71) | −0.217 (p = 0.22) |
| Neutrophils | −0.218 (p = 0.03) | −0.188 (p = 0.07) | 0.215 (p = 0.04) | −0.197 (p = 0.05) | 0.215 (p = 0.04) | 0.146 (p = 0.42) | 0.137 (p = 0.44) |
| NLR | −0.276 (p = 0.006) | −0.110 (p = 0.28) | 0.345 (p < 0.001) | −0.052 (p = 0.61) | 0.333 (p < 0.001) | 0.027 (p = 0.88) | 0.218 (p = 0.22) |
| Haptoglobin | 0.204 (p = 0.04) | 0.351 (p < 0.001) | 0.180 (p = 0.08) | 0.335 (p < 0.001) | −0.059 (p = 0.56) | 0.478 (p = 0.005) | −0.066 (p = 0.72) |
ED Creatinine, emergency department creatinine; ADAMTS13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; vWF, Ag, von Willebrand factor antigen; CRP, C reactive protein; IL-6, interleukin-6; LDH, lactate dehydrogenase; NLR, neutrophil to lymphocyte ratio; CH50, 50% hemolytic complement activity. Statistical significance denoted with bold text.