Table 3.

Change from baseline in the average pain intensity score using mixed-model repeated-measures, intent-to-treat population.

Visit	No. of patients		Least-square estimates (mean)		Treatment A-B
	ISC 17536 (treatment A)	Placebo (treatment B)	ISC 17536	Placebo	LS mean difference	95% confidence interval
Week 1	70	66	−0.86	−0.46	−0.40	(−0.89, 0.09)
Week 2	70	65	−1.24	−1.02	−0.22	(−0.71, 0.28)
Week 3	65	62	−1.65	−1.33	−0.32	(−0.82, 0.18)
Week 4	70	66	−1.95	−1.68	−0.27	(−0.76, 0.22)
Week 6	63	62	−2.41	−2.16	−0.25	(−0.75, 0.26)

Model: Change from baseline in the API score = treatment + week + treatment*week + baseline API + patient as a random effect.

ITT, intent-to-treat.