Figure 1.

Variants of tissue pro-inflammatory stress. 1—Physiological variants of TS; 2—Non-classical low-grade inflammation (para-inflammation), which at systemic level may be manifest as stably altered homeostasis (allostasis); 3—Classical inflammation (the organism’s response to a significant local injury) is characterized by the presence of its attribute—a focus of inflammation and, in some cases, a systemic inflammatory response aimed at resourcing the focus of inflammation; 4—Life-critical systemic inflammation, the key phenomenon of which is a systemic microvascular response comparable in intensity to the local response in the focus of classical inflammation.