Table 4.
Univariate Cox proportional hazards models for 5-year death censored and non-death censored graft survival with hazard ratios (HR) and 95% confidence intervals (CI) for donor, recipient and transplant associated factors.
| Death censored graft survival HR (95% CI) | p-value | Non-death censored graft survival HR (95% CI) | p-value | |
|---|---|---|---|---|
| Donor associated | ||||
| (L)KDPI | 1.197 (1.085–1.320) | <0.001 | 1.221 (1.129–1.231) | <0.001 |
| KDPI | 1.297 (1.153–1.459) | <0.001 | 1.259 (1.164–1.361) | <0.001 |
| LKDPI | 0.852 (0.660–1.099) | 0.229 | 0.951 (0.782–1.157) | 0.659 |
| ECD | 2.602 (1.539–4.397) | <0.001 | 2.223 (1.509–3.275) | <0.001 |
| Age | 1.038 (1.018–1.059) | <0.001 | 1.039 (1.024–1.055) | <0.001 |
| Gender (f) | 1.019 (0.610–1.702) | 0.943 | 1.271 (0.866–1.864) | 0.221 |
| Height | 0.995 (0.973–1.017) | 0.660 | 0.989 (0.975–1.003) | 0.115 |
| Weight | 1.008 (0.993–1.024) | 0.308 | 1.000 (0.988–1.013) | 0.949 |
| History of | ||||
| Hypertension | 2.347 (1.381–3.988) | 0.002 | 1.656 (0.114–2.459) | 0.012 |
| Diabetes | 4.471 (2.462–8.119) | <0.001 | 2.973 (1.818–4.863) | <0.001 |
| Smoking | 0.508 (0.264–0.979) | 0.043 | 0.400 (0.243–0.659) | <0.001 |
| Cause of death: CVA | 1.888 (1.026–3.474) | 0.041 | 1.950 (1.240–3.067) | 0.004 |
| Last SCr | 0.820 (0.492–1.366) | 0.445 | 0.818 (0.557–1.201) | 0.305 |
| Recipient associated | ||||
| Age | 1.023 (1.001–1.046) | 0.036 | 1.047 (1.028–1.066) | <0.001 |
| BMI | 1.050 (0.999–1.104) | 0.057 | 1.015 (0.976–1.056) | 0.458 |
| Gender (f) | 0.929 (0.545–1.585) | 0.787 | 0.732 (0.483–1.111) | 0.143 |
| CCI | 1.047 (0.832–1.318) | 0.696 | 1.326 (1.142–1.540) | <0.001 |
| Reason for ESKD | ||||
| Glomerulonephritis | 0.717 (0.399–1.288) | 0.266 | 0.618 (0.392–0.975) | 0.039 |
| Diabetes | 1.639 (0.778–3.456) | 0.194 | 2.014 (1.198–3.386) | 0.008 |
| Hypertension | 0.511 (0.204–1.279) | 0.152 | 1.137 (0.684–1.890) | 0.621 |
| Duration of dialysis | 1.005 (0.998–1.011) | 0.145 | 1.003 (0.998–1.008) | 0.259 |
| Transplant associated | ||||
| Living vs. deceased donation | 1.745 (0.882–3.452) | 0.109 | 2.150 (1.243–3.719) | 0.006 |
| CIT | 1.022 (0.981–1.065) | 0.297 | 1.042 (1.011–1.074) | 0.007 |
| WIT | 1.011 (1.002–1.019) | 0.011 | 1.009 (1.002–1.017) | 0.012 |
| Number of HLA-mismatches | 1.318 (1.090–1.595) | 0.004 | 1.263 (1.099–1.452) | 0.001 |
| PRA | 1.013 (1.006–1.021) | 0.001 | 1.007 (1.000–1.014) | 0.039 |
| DGF | 2.138 (1.191–3.839) | 0.011 | 1.514 (0.996–2.302) | 0.052 |
| Number of BPR in first year | 2.021 (1.607–2.541) | <0.001 | 1.802 (1.483–2.190) | <0.001 |
| Number of all BPR | 0.613 (0.421–0.894) | 0.011 | 0.670 (0.506–0.886) | 0.005 |
| eGFR after 3 years | 0.957 (0.931–0.983) | 0.001 | 0.967 (0.949–0.986) | 0.001 |
HR and CI were calculated per 10% increase of the (L)KDPI. BMI, Body Mass Index; BPR, biopsy-proven rejection; CCI, Charlson Comorbidity Index; CIT, cold ischemia time; CVA, cerebro-vascular accident; DGF, delayed graft function; eGFR, estimated glomerular filtration rate; ESKD, end stage kidney disease; HLA, Human leukocyte antigen; (L)KDPI, (Living) Kidney Donor Profile Index; PRA, panel-reactive antibody; SCr, Serum creatinine; TX, transplantation; WIT, warm ischemia time.
Statistically significant p-values are printed in bold.