Figure 1.

The role of Notch, SHH, and Wnt signaling pathways in anticancer therapy resistance. Abbreviations: SHH—Sonic hedgehog, SUFU—protein domain suppressor of fused protein, GLI—zinc finger protein, NECD—Notch extracellular domain, NICD—Notch intracellular domain, CSCs—cancer stem cells, ROS—reactive oxygen species, Jag—Notch ligand Jagged, Dll—delta-like ligand, Hes—hairy and enhancer of split, Myc—family of regulator genes and proto-oncogenes, point arrow—activation, block arrow—inhibition.