TABLE 1.

Oral microorganisms with varying abundances in different oral diseases.

Oral disease	Pathogens in traditional research	Oral microorganism with increased abundance from sequencing investigation	Oral microorganism with decreased abundance from sequencing investigation	References
Caries	Genera: Actinomyces, Lactobacillus, Neisseria, Porphyromonas, Prevotella, Propionibacterium, Streptococcus Species: Actinomyces israelii, A. viscosus, Lactobacillus acidophilus, L. casei, L. fermentum, Streptococcus mitis, S. mutans, S. sanguinis Others: Candida albicans	Genera: Bifidobacterium, Haemophilus, Legionella, Neisseria, Prevotella, Propionibacterium, Rothia, Shuttleworthia, Veronococcus Species: Porphyromonas catoniae, Prevotella histicola, S. mutans, Veillonella dispar Others: C. albicans, EBV	Genera: Anaerosporobacter, Caldicoprobacter, Dysgonomonas, Hespellia, Proteiniphilum, Species: Capnocytophaga granulosa, Leptotrichia buccalis,	Xiao et al., 2018b; Hurley et al., 2019; Baker et al., 2021; Zheng et al., 2021
Periodontal disease	Genera: Fusobacterium, Parvimonas, Prevotella Species: Actinobacillus actinomycetemcomitans, A. viscosus, P. gingivalis, Tannerella forsythia, Treponema denticola, Others: Cytomegalovirus, EBV, HSV-1	Genera: Desulfobulbus, Eubacterium, Filifactor, Fretibacterium, Parvimonas, Porphyromonas, Prevotella, Tannerella, Treponema, Species: Filifactor alocis, P. denticola, P. endodontalis, P. gingivalis, T. denticola, T. forsythia Others: Redondoviridae	Genera: Actinomyces, Capnocytophaga, Corynebacterium, Neisseria, Rothia, Streptococcus Species: C. gingivalis, C. ochracea, Neisseria subflava, P. catoniae, Rothia aeria, S. infantis, S. mitis, S. oralis, S. sanguinis	Abusleme et al., 2013; Galimanas et al., 2014; Chen et al., 2018; Pérez-Chaparro et al., 2018; Ikeda et al., 2020
Pulp periapical disease	Genera: Actinomyces, Bacteroides, Enterococcus, Fusobacterium, Peptostreptococcus, Porphyromonas, Prevotella, Saccharomycodes, Streptococcus Species: Enterococcus faecalis, Peptostreptococcus micros, P. endodontalis, P. gingivalis, P. melaninogenicus	Genera: Aggregatibacter, Fusobacterium, Lactobacillus, Peptostreptococcus, Porphyromonas, Prevotella, Schwartzia, Slackia, Treponema Species: Dialister invisus, E. faecalis, Fusobacterium nucleatum, P. gingivalis, P. micros, T. denticule Others: C. albicans, HSV	Genera: Acinetobacter, Actinomyces, Corynebacterium, Granulicatella, Haemophilus, Leptotrichia, Staphylococcus, Streptococcus Species: N. subflava, P. melaninogenica, P. nanceiensis, R. mucilaginosa	Dingsdag et al., 2016; Qian et al., 2019; Zheng et al., 2019; Zargar et al., 2020; Cai W. Y. et al., 2021
Oral cancer	Species: F. nucleatum, P. gingivalis Others: HPV	Genera: Aggregatibacter, Alloprevotella, Capnocytophaga, Fusobacterium, Parvimonas, Peptostreptococcus, Porphyromona, Prevotella, Treponema Species: Catonella morbi, F. nucleatum, F. periodonticum, Haemophilus influenza, P. intermedia, Parvimonas micra, S. constellatus, T. alocis, T. denticola Others: Candida, Gibberella	Genera: Acitinomyces, Haemophilus, Lautropia, Porphyromonas, Rothia, Streptococcus, Veillonella Species: A. odontolyticus, H. parainfluenzae, P. pasteri, S. mitis, S. oralis, V. parvula	Zhao et al., 2017; Yang C. Y. et al., 2018; Zhang et al., 2019
Recurrent oral ulcer	Genera: Streptococcus Species: Helicobacter pylori, S. sanguinis	Genera: Actinobacillus, Alloprevotella, Fusobacterium, Haemophilus, Porphyromonas, Prevotella, Vibrio Species: C. gingivalis, C. sputigena, Escherichia coli, F. nucleatum, H. parahaemoliticus, H. parainfluenzae, N. flavescens, N. sicca Others: C. albicans, Malassezia	Genera: Streptococcus, Veillonella Species: Gemella haemolysans, S. oralis, S. salivarius, V. dispar Others: Cladosporium sp.	Kim et al., 2016; Stehlikova et al., 2019; Yang et al., 2020; Zhu et al., 2021
Peri-implantitis	Genera: Fusobacterium, Parvimonas, Staphylococcus Species: P. gingivalis, T. denticola,	Genera: Eubacterium, Filifactor, Fretibacterium, Porphyromonas, Tannerella, Treponema Species: A. cardiffensis, E. minutum, Eubacterium infirmum, Fretibacterium fastidiosum, G. sanguinis, Kingella denitrificans, L. hofstadii, P. gingivalis, P. intermedia, T. alocis, T. denticola, T. forsythia, T. maltophilum,	Genera: Actinomyces, Haemophilus, Rothia, Streptococcus, Veillonella Species: A. cardiffensis, E. infirmum, R. dentocariosa, S. sanguinis, V. dispar	Zheng et al., 2015; Sanz-Martin et al., 2017; Ghensi et al., 2020