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. 2022 May 9;23(9):5270. doi: 10.3390/ijms23095270

Figure 3.

Figure 3

Compound A protects against airway inflammation and mucin secretion in FFA4-WT mice. (A) Panels show H&E-stained sections of lung tissues from the PBS group, OVA group, and compound A-treated OVA groups (before sensitization or before challenge). Small navy-blue dots around the bronchioles indicate eosinophils. Eosinophils are accumulated around bronchioles in the OVA group (green arrows). (B) Panels show PAS/hematoxylin-stained sections of lung tissues from the PBS group, OVA group, and compound A-treated OVA groups (before sensitization or before challenge). In PAS staining, mucin is stained as a purple color. Darker and thicker purple coloring is observed surrounding the bronchiole in the OVA group compared to the PBS group. (C) Lung inflammation was semi-quantitatively evaluated; histological findings were scored as described in Section 4. (D) Mucous production was measured by counting the number of PAS-positive cells per mm of bronchiole (n = 5 per group). Values represent the means ± SEM (n = 5). *** p < 0.001 vs. the PBS-treated group, ## p < 0.01, ### p < 0.001 vs. the OVA-treated group.