Table 2.
Cancer prognostic summary of the main phospholipid enzymes. Immunostaining was performed on cancer biopsies from 20 patients with n = 4–12 samples per cancer. Proteins whose expression is significantly (p < 0.001) associated with patient survival are determined to be a prognostic marker for that cancer. Data are obtained from The Human Protein Atlas (https://www.proteinatlas.org/ (accessed on 12 April 2021)).
| Protein | Role | Cancer Type | Outcome | % of Patients with Increased Expression |
|---|---|---|---|---|
| CKα | Phosphorylation of choline |
Liver cancer | Unfavorable | 16 |
| ETNK1 | Phosphorylation of ethanolamine |
Urothelial cancer Liver cancer |
Favorable Unfavorable |
25 16–33 |
| PCYT2 | Formation of CDP-ethanolamine |
Renal cancer | Favorable | 33–36 |
| PEMT | Methylation of PE to PC | Endometrial cancer | Favorable | 33 |
| SELENO1 | Formation of PE | No | N/A | N/A |