Figure 3.

Development of colitis-associated colon cancer is not altered in P-cadherin knockout mice. Control and P-cadherin KO mice were injected intraperitoneally with AOM and subjected to three cycles of DSS exposure and recovery. Mice were euthanized and their colonic polyps were counted and examined. (A) An endoscopic view of the colonic polyps (arrows). (B) Overall view of the dissected colonic segments with tumors (arrowheads). (C) Number of developed colonic tumors. (D) Representative hematoxylin and eosin staining of the colonic sections showing high grade neoplasia and low grade neoplasia in control and P-cadherin knockout mice, respectively. (E) The histopathology score. Number of animals of each group is shown in parentheses. * p < 0.05; n.s., not significant, p = 0.594. Data were combined from two independent experiments.