Table 2.

Literature search of 40 identified “ULA-norm-Ad” hits in relation to their role in cancer.

Gene ID	Function/Expression	Type of Cancers	#
hsa-miR-137	Tumor suppressor Anchorage-independent growth reduction	Cervical [24,25,26,27,28], melanoma [29], acute lymphoblastic leukemia [30], pituitary adenoma [31], prolactinomas [32], pancreatic [33], endometrial [34], colon [35], glioblastoma [36], melanoma [37], bladder [38], liver [39], pancreatic [40], and other	305
hsa-miR-129-5p	Tumor suppressor	Cervical [8,41,42,43], gastric [44,45], prostate [46], lung [47,48], colon [49], breast [50], pancreatic [51], liver [52], bladder [53], many other	159
hsa-miR-491-5p	Tumor suppressor	Cervical [54,55,56], colon [57], osteosarcoma [58], gastric [59], many others	49
hsa-miR-193b-3p	Tumor suppressor	Cervical [60], lung [61], ovarian [62], gastric [63], acute myeloid leukemia [64]	43
hsa-miR-532-3p	Tumor suppressor Downregulated	Cervical [65], colon [66], lung [67], lymphoma [68], prostate [69], tongue [70], breast [71] and other	36
hsa-miR-646	Tumor suppressor	Cervical [72], breasts [73], lung [74], gastric [75], many others	31
hsa-miR-185-3p	Tumor suppressor Downregulated	Cervical [76], prostate [77], colon [78], osteosarcoma [79], breast [80], nasopharyngeal [81], and other	21
hsa-miR-1287	Tumor suppressor Downregulated	Cervical [82,83], breast [83,84,85,86,87,88], liver [87], colon [89], pancreatic [90], lung [88] and other
hsa-miR-22-5p	Tumor suppressor Downregulated	Cervical [65,91,92,93], osteosarcoma, prostate, lung [93], and other	16
hsa-miR-378c	Tumor suppressor Prognostic marker	Cervical [94], gastric [95], Wilms tumor [96], head and neck [97]	12
hsa-miR-193a-3p	Tumor suppressor	Lung [98,99,100], esophageal [101], liver [102], renal [103], osteosarcoma [104], colon [105], many others	107
hsa-miR-608	Tumor suppressor	Prostate [106], bladder [107], lung [108]	80
hsa-miR-342-5p	Tumor suppressor	Breast [109,110,111], ovarian [112], colon [113], osteosarcoma [114], neuroblastoma [115,116]	27
hsa-miR-4270	Tumor suppressor	Lung [117,118], liver [119]	10
hsa-miR-103a-2-5p	Tumor suppressor	Prostate [120], tongue [121], colon [122]	5
hsa-miR-4749-5p	Tumor suppressor	Glioblastoma [123]
hsa-miR-1911-3p	Tumor suppressor	Lung [124]
hsa-miR-1250	Tumor suppressor	Non-Hodgkin’s lymphoma [125]
hsa-miR-323a-5p	Tumor suppressor	Neuroblastoma [115,116]
hsa-miR-3680-3p	Tumor suppressor	Esophageal [126]
hsa-miR-1272	Tumor suppressor	Prostate [127]
hsa-miR-5189	Prognostic marker	Childhood B-cell acute lymphoblastic leukemia [128]
hsa-miR-4430	Downregulated Prognostic marker	Ovarium [129]
hsa-miR-224-3p	OncomiR	Cervical [130,131], osteosarcoma [132], lung [133]	15
hsa-miR-766-5p	Upregulated, OncomiR	Cervical [134], promotes other cancers	6
hsa-miR-3147	Upregulated, OncomiR Prognostic marker	Cervical [135], vulvar [136]	2
hsa-miR-522-3p	OncomiR	Lung [137,138], colon [139]	12
hsa-miR-425-3p	Upregulated Prognostic marker	Liver [140], gastric [141], prostate [142], lung [143,144], colon [145]	11
hsa-miR-1233-1-5p	Upregulated	Renal [146,147] esophageal [148]
hsa-miR-3916	Upregulated, OncomiR	Melanoma [149], urothelial tract [150]
hsa-miR-4440	Upregulated Prognostic marker	Colon [151]
hsa-miR-4505	Upregulated Prognostic marker	Gastric [152]
No (cancer related) publications: hsa-miR-2277-5p, hsa-miR-4498, has-miR-5681a, has-miR-4436b-3p, hsa-miR-4706, hsa-miR-1263, hsa-miR-4265, hsa-miR-4746-3p

# Number of cancer-related publications. For each miRNA we performed search in Pubmed using the word “cancer” and the number of listed publications is noted in the last column. miRNAs are sorted based on their relevance to cervical cancer following with the relevance to other cancers and the number of publications starting with tumor suppressive miRNAs and following with oncomiRs.