TABLE 3.
Odds ratio and related 95% confidence intervals expressing the association between individual predictive variables and the anatomic spread of adult-onset isolated dystonia in the two predictive models
| Dystonia-only | Dystonia or tremor | |||
|---|---|---|---|---|
| AUC (95% CI) | ||||
| Original cohort | 0.67 (0.64–0.71) | 0.66 (0.63–0.70) | ||
| Index-corrected | 0.65 [0.62–0.70) | 0.65 [0.62–0.69) | ||
| Estimate (SE) | OR (95% CI) | Estimate (SE) | OR (95% CI) | |
| Agea | 0.23 (0.10) | 1.26 (1.04–1.54) | 0.36 (0.09) | 1.43 (1.19–1.72) |
| Female vs. male | 0.09 (0.16) | 1.10 (0.79–1.51) | −0.01 (0.15) | 0.99 (0.73–1.34) |
| Depressed | 0.42 (0.17) | 1.52 (1.09–2.13) | 0.46 (0.17) | 1.58 (1.14–2.19) |
| Onset sites | ||||
| Cranial vs. cervical | 1.29 (0.19) | 3.63 (2.52–5.23) | 0.93 (0.17) | 2.52 (1.79–3.55) |
| Other onset sites vs. cervical | 0.65 (0.19) | 1.91 (1.31–2.78) | 0.77 (0.19) | 2.15 (1.49–3.11) |
| Neck trauma | 0.70 (0.32) | 2.01 (1.08–3.72) | 0.70 (0.32) | 2.01 (1.08–3.72) |
| Disease durationa | 0.14 (0.10) | 1.15 (0.95–1.39) | 0.46 (0.31) | 1.59 (0.87–2.90) |
| “Tremor-dominant” dystonia | 0.35 (0.23) | 1.42 (0.52–2.22) | ||
| Family history | 0.41 (0.21) | 1.51 (0.99–2.28) | ||
| Head trauma | 0.38 (0.25) | 1.47 (0.89–2.42) |
Abbreviation: AUC, area under the receiver-operating characteristic curve; CI, confidence interval; OR, odds ratio.
a
Age interquartile range = 15.5 years, with the first quartile (Q1) = 53.5 years old and the third quartile (Q3) = 69 years old; disease duration interquartile range = 13 years, with Q1 = 4 years and Q3 = 17 years.