Table 2.
Effective half-maximal inhibitory concentrations (IC50) of piperine (1), piperic acid (2), and N-aryl amide analogs of piperine (3–5) against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
| Compounds | IC50 ± S.E.M. (μM) | |
|---|---|---|
| Antitrypanosomal against T. brucei rhodesiense |
Antimalarial against 3D7 P. falciparum |
|
| Piperine (1) | 56.67 ± 0.98 | 61.24 ± 2.83 |
| Piperic acid (2) | >100 | 63.54 ± 2.43 |
| 3 | 53.53 ± 1.77 | 25.82 ± 1.56 |
| 4 | 19.87 ± 2.28 | 29.41 ± 3.54 |
| 5 | 15.46 ± 3.09 | 24.55 ± 1.91 |
| Pentamidine a | 0.016 ± 0.002 | n.d. |
| Pyrimethamine b | n.d. c | 0.117 ± 0.017 |
aPositive control for antitrypanosomal; b Positive control for antimalaria; c n.d. refers to not determined.