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Inhibitory activity of SARS-CoV-2 3C-like main protease with piperine (1), piperic acid (2), and N-aryl amide analogs of piperine (3–5).
| Compounds | Relative Protease Activity at 100 μM. (%RFU/s a ± S.D.) |
IC50 ± S.D. (μM) |
|---|---|---|
| Rutin | 60.3 ± 2.4 | 325.6 ± 12 |
| Piperine (1) | 31.0 ± 2.8 | 178.4 ± 1.2 |
| Piperic acid (2) | 46.9 ± 1.4 | n.d. b |
| 3 | 55.1 ± 1.1 | n.d. |
| 4 | 69.0 ± 6.1 | n.d. |
| 5 | 31.8 ± 5.7 | 106.9 ± 1.2 |
a RFU/s refers to relative fluorescence unit per second. b n.d. refers to not determined.
