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. 2022 Apr 29;13:868480. doi: 10.3389/fimmu.2022.868480

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Copyright © 2022 Hong, Liu, Liang, Zhang, Li, Han, Du, Chen and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TTK patterns vary with respect to the metabolic microenvironment. (A) GSVA enrichment analysis disclosing biological pathway differences between TTK patterns. The heatmap was generated to visualize these biological processes; red represents activated pathways and blue represents inhibited pathways. (B) Scatter plot showing median expression levels of co-expressed glycolytic (x-axis) and cholesterogenic (y-axis) genes in each HCC sample. Metabolic subgroups were assigned on the basis of the relative expression levels of glycolytic and cholesterogenic genes. (C) Kaplan–Meier survival analysis of patients with HCC stratified by four metabolic subtypes clustered by glycolytic and cholesterogenic genes. (D) Circle diagram shows HCC subtypes for each sample and investigated their degree of overlap with TTK patterns, immune subtypes and metabolic phenotypes.