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. Author manuscript; available in PMC: 2022 May 13.
Published in final edited form as: DNA Repair (Amst). 2017 May 20;55:76–82. doi: 10.1016/j.dnarep.2017.05.005

Figure 3. ICL lesion bypass by CMG helicases at converging forks.

Figure 3.

p97 and BRCA1, together with leading strand DNA synthesis, promote CMG helicases to unload at the converging fork. Reloading occurs on the distal side of the ICL.