Table 1.
Data extracted from rodent studies: topic, study design, age, sample and treatments.
| Article | Main Topic | Study Design | Age-Strain | Ovariectomy | n-3 PUFA Treatment Details |
|---|---|---|---|---|---|
| Dornellas et al. [64] | Anxiety and Depression | Preclinical study | 8 weeks old; Wistar Rats |
X | Fish Diet: standard chow enriched with fish oil. The high-fat diets were prepared by adding, to the standard chow, 20% (w/w) fish oil, 20% (w/w) casein, 10% (w/w) sucrose, and 0.02% (w/w) butylated hydroxytoluene; duration: 8 weeks. |
| Wu et al. [65] | Anxiety and Depression | Preclinical study | 12 weeks old; Sprague Dawley Rats |
X | Refined fish oil administrated daily by gavage (1.5 g/kg, approximately 340 mg/g for EPA, 240 mg/g for DHA); duration: 10 weeks. |
| Da Rocha et al. [66] | Anxiety and Depression | Preclinical study | 8 weeks old; Wistar Rats |
X | Supplementation performed 20 days before and 20 days after the surgical procedure: daily dose of 500 mg/kg/day of omega-3 (1000 mg capsules, containing 180 mg of EPA and 120 mg of DHA); duration: 40 days. |
| Jin et al. [67] | Depression | Preclinical study | 3 weeks old; Wistar Rats |
X (after 8 weeks of supplementation) |
The diets were isocaloric and modified with 0%, 1% or 2% EPA + DHA relative to the total energy intake (0 g, 8.09 g and 16.21 g of fish oil per kg of diet, respectively). The diets contained 10% of total energy from fat, with 42.94 g/kg diet of fish oil and grape seed oil; duration: 12 weeks. |
| Choi et al. [68] | Depression | Preclinical study | 3 weeks old; Wistar Rats |
X (after 8 weeks of supplementation) |
Diets were isocaloric modified with 0% n-3 PUFA, 1% ALA, 1% EPA or 1% DHA relative to the total energy intake. The control diet contained 70 g/kg of grape seed oil; the ALA, EPA and DHA diets contained 8.27 g/kg of flaxseed oil, 4.46 g/kg of EPA EE and 4.67 g/kg of DHA EE, respectively. The control diet had 0.05% of n-3 PUFA, and the ALA, EPA and DHA diets had 6.40% of ALA, 6.35% of EPA and 6.35% of DHA in total fatty acids, respectively; duration: 12 weeks. |
| Konuri et al. [69] | Cognition | Preclinical study | 9–10 months; Wistar Rats |
X | Choline (4.6 mmol/kg/day) in combination with DHA (300 mg/kg/day); duration: 30 days. |
Abbreviations: ALA, alpha lipoic acid; DHA, docosahexaenoic acid; EE, ethyl ester; EPA, eicosapentaenoic acid; n-3 PUFA, Omega-3 polyunsaturated fatty acids.