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. 2022 May 6;23(9):5190. doi: 10.3390/ijms23095190

Figure 1.

Figure 1

GSK treatment induces the reactivation of MIO-M1 cells and gliosis, and statins suppress these events. MIO-M1 cells were treated with GSK101 alone for 24 h or pretreated with each statin for 6 h, followed by GSK101 treatment for 24 h. Then, cells were stained for the expression of (A) vimentin, (B) nestin, and (C) GFAP, which are the indicators of gliosis. The nucleus was labeled with DAPI. GSK101 at 25 nM increased vimentin, nestin, and GFAP expression. Statins pretreatment at 10 nM attenuated these expressions. n = 4 for each figure.