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. 2022 May 6;23(9):5190. doi: 10.3390/ijms23095190

Figure 2.

Figure 2

GSK treatment induces TNF-α and pretreatment with statins suppress it. TNF-α production was 14-fold greater than at a 1 nM concentration (A). GSK101-mediated induction of TNF-α levels suppressed by pretreatment with statins. MIO-M1 cells were treated either with GSK101 alone for 24 h or pretreated with (B) simvastatin, (C) atorvastatin, or (D) lovastatin for 1 h and then followed by GSK101 treatment for 24 h with 50 nM GSK101. Pretreatment with statins suppressed TNF-α production from 1 nM concentrations. Asterisks indicate statistical significance. * p < 0.05, ** p < 0.01. n = 4 for each figure.