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. 2022 May 6;23(9):5190. doi: 10.3390/ijms23095190

Figure 5.

Figure 5

Statins attenuate GSK-mediated IκBα phosphorylation, which occurs upstream of p65 activation. MIO-M1 cells were treated either with GSK101 alone for 24 h or pretreated with simvastatin, atorvastatin, or lovastatin for 6 h, followed by GSK101 treatment for 24 h. Then, cells were fixed and stained for pIκBα. Pretreatment with 10 nM statins prior to GSK101 treatment suppressed IκBα phosphorylation. All three statins were potent attenuators of GSK-mediated IκBα phosphorylation upstream of p65 activation in Müller glial MIO-M1 cells. n = 4.