Figure 1.

Differential mRNA expression. The basal cardiac gene expression profile of PP2A overexpressing (PP2A-TG) and littermate wild type (WT) mouse hearts was analyzed by a mouse genome gene chip. Data are presented as ratio of the mean PP2A-TG signal divided by the mean WT signal ± SD. More detailed data can be found in the supplementary Tables S1–S3 and supplementary Figures S1–S4. (A) Several subunits of different protein phosphatases are summarized. (B) A selection of genes with various functions is shown. The abbreviations are: aldehyde dehydrogenase 2 (Aldh2), Ca²⁺ calmodulin kinase II (CamKII), cardiac calsequestrin (CSQ2), endonuclease G (Endog), glycerin aldehyde phosphate dehydrogenase (GAPDH), heat shock protein 25 (HSP25), nitric oxide synthase 3 (NOS3), nucleoporin 62kDa (Nup62), proliferating cell nuclear antigen (PCNA), superoxide dismutase 2 (SOD2). Three RNA samples from each genotype (n = 3) were studied. * p < 0.05 vs. WT (by comparison of individual data sets).