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. 2022 Apr 22;11(9):1429. doi: 10.3390/cells11091429

Figure 5.

Figure 5

Deregulation of astrocytic protein upon exposure to tau. (a) Immunoblots using antibody against proteins EAAT-2, phosphoPKC II (pPKCα/β), total PKC II (tPKCα/β), phosphoERK1/2 (pERK1/2), total ERK1/2 (tERK1/2), pro- and active MMP-9 and MMP-2. Actin was used as loading control. Graph showing levels of (b) EAAT-2, (c) phospho/total PKCα/β, (d) phospho/total ERK1/2, (e) pro-MMP9, (f) active-MMP9, (g) pro-MMP2, and (h) active-MMP2 in astrocytes between the untreated and monomeric and aggregated tau-treated groups. One-way ANOVA followed by Tukey’s test for multiple analysis was used for statistical analysis (n = 3/group; n = 3 experimental repeats), * p < 0.05, ** p < 0.01, and *** p < 0.001.