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. 2022 Apr 29;14(9):1854. doi: 10.3390/nu14091854

Figure 1.

Figure 1

Schematic representation of VDES metabolism and the main genes involved. The CYP2R1, CYP27B1, CYP24A1, and CYP3A4 genes encode the enzymes vitamin D 25-hydroxylase, 25-hydroxyvitamin D3-1-alpha-hydroxylase, vitamin D 24-hydroxylase and cytochrome P450 3A4, respectively. The VDR gene encodes the vitamin D receptor. The DHCR7 gene encodes delta-7-dehydrocholesterol reductase. The HNRNPC gene encodes Heterogeneous Nuclear Ribonucleoprotein C. VDDR1A, vitamin D-dependent rickets type 1A; VDDR1B, vitamin D hydroxylation-deficient rickets type 1B; VDDR2A, vitamin D-dependent rickets type 2A; VDDR2B, vitamin D-dependent rickets type 2B with normal vitamin D receptor; VDDR3, dominant vitamin D-dependent rickets type 3.