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Magnitude ratings of spontaneous (background) sensations of burning and pain referred to the sites of application of blank and capsaicin filled NPs. (A) Magnitude of burning, (B) magnitude of pain. Mean ± SD, n = 21, mixed effect model 2 within subject treatments (capsaicin vs. placebo treatment) × 14 repeated timepoints (0–90 h) with Bonferroni correction. * p < 0.05, ** p < 0.01, **** p < 0.0001 for blank vs. NP comparison.
