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. 2022 May 9;23(9):5275. doi: 10.3390/ijms23095275

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of capsaicin NP pretreatment on sensations and dysesthesias evoked by injection of beta alanine. (A–C) Time course of perceived intensities of itch, pricking/stinging and burning. Same format as Figure 7. (D) Peak magnitude (Peak) of each sensory quality. (E) Area under the rating curve (AUC). (F) Duration of response. (G) Area of each type of dysesthesia: alloknesis, hyperalgesia and hyperknesis. n = 21, (A–C) repeated measures two-way ANOVA; two repeated treatment groups (capsaicin vs. placebo treatment) × 40 repeated timepoints (0–20 min) with Bonferroni correction, (D–G) Wilcoxon test. Data are means with SEMs. * p < 0.05 and ** p < 0.01and *** p < 0.001.