Figure 8.

Effects of capsaicin NP pretreatment on sensations and dysesthesias evoked by injection of BAM8-22. (A–C) Time course of perceived intensities of itch, pricking/stinging, and burning. Same format as Figure 7. (D) Peak magnitude (Peak) of each sensory quality. (E) Area under the rating curve (AUC). (F) Duration of response. (G) Area of each type of dysesthesia: alloknesis, hyperalgesia and hyperknesis. n = 21, (A–C) repeated measures two-way ANOVA; two repeated treatment groups (capsaicin vs. placebo treatment) × 40 repeated timepoints (0–20 min) with Bonferroni correction, (D–G) Wilcoxon test. Data are means with SEMs. * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001.